Article
Analysis of the rdd locus in chicken: a model for human retinitis pigmentosa.
Molecular vision - 30 Apr 2003
Burt David W, Morrice David R, Lester Douglas H, Robertson Graeme W, Mohamed Moin D, Simmons Ian, Downey Louise M, Thaung Caroline, Bridges Leslie R, Paton Ian R, Gentle Mike, Smith Jacqueline, Hocking Paul M, Inglehearn Chris F
Abstract excerpt
PURPOSE: To identify the locus responsible for the blind mutation rdd (retinal dysplasia and degeneration) in chickens and to further characterise the rdd phenotype. METHODS: The eyes of blind and sighted birds were subjected to ophthalmic, morphometric and histopathological examination to confirm and extend published observations. Electroretinography was used to determine age of onset. Birds were crossed to...
Topics
- Animals
- Blindness
- Chickens
- Chromosome Mapping
- Chromosomes
- Crosses, Genetic
- DNA Mutational Analysis
- Disease Models, Animal
- Electroretinography
- Female
- Genetic Linkage
- Genotype
- Male