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Article

GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice.

Scientific reports - 15 Feb 2017

DeRamus Marci L, Stacks Delores A, Zhang Youwen, Huisingh Carrie E, McGwin Gerald, Pittler Steven J

Abstract excerpt

The Cngb1 locus-encoded β-subunit of rod cGMP-gated cation channel and associated glutamic acid rich proteins (GARPs) are required for phototransduction, disk morphogenesis, and rod structural integrity. To probe individual protein structure/function of the GARPs, we have characterized several transgenic mouse lines selectively restoring GARPs on a Cngb1 knockout (X1-/-) mouse background. Optical coherence...

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Identifiers

PMID: 28198469
DOI: 10.1038/srep42545
PMCID: PMC5309851

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ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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