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Article

CTLA-4 gene polymorphism is associated with predisposition to coeliac disease.

Gut - 1 Aug 1998

Djilali-Saiah I, Schmitz J, Harfouch-Hammoud E, Mougenot J F, Bach J F, Caillat-Zucman S

Abstract excerpt

BACKGROUND: Susceptibility to coeliac disease is strongly associated with particular HLA class II alleles. However, non-HLA genetic factors are likely to be required for the development of the disease. Among candidate genes is the CTLA-4 (cytotoxic T lymphocyte associated) gene located on chromosome 2q33 in humans, which encodes a cell surface molecule providing a negative signal for T cell activation. AIMS: To...

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Source

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Identifiers

PMID: 10189842
DOI: 10.1136/gut.43.2.187
PMCID: PMC1727221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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