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Article

Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

The Journal of biological chemistry - 15 Apr 2005

Kubatzky Katharina F, Liu Wei, Goldgraben Kerri, Simmerling Carlos, Smith Steven O, Constantinescu Stefan N

Abstract excerpt

The erythropoietin receptor (EpoR) is crucial for erythrocyte formation. The x-ray crystal structures of the EpoR extracellular domain lack the juxtamembrane (JM) region and the junction to the transmembrane (TM) domain. Yet the JM-TM regions are important for transmitting the conformational change imposed on the receptor dimer by Epo binding. Cysteine-scanning mutagenesis of the JM-TM regions identified three...

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Identifiers

PMID: 15657048
DOI: 10.1074/jbc.M411251200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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