Article
Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor.
Current biology : CB - 23 Jan 2001
Kubatzky K F, Ruan W, Gurezka R, Cohen J, Ketteler R, Watowich S S, Neumann D, Langosch D, Klingmüller U
Abstract excerpt
Hematopoietic cytokine receptors, such as the erythropoietin receptor (EpoR), are single membrane-spanning proteins. Signal transduction through EpoR is crucial for the formation of mature erythrocytes. Structural evidence shows that in the unliganded form EpoR exists as a preformed homodimer in an open scissor-like conformation precluding the activation of signaling. In contrast to the extracellular domain of...
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