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Article

Expression of a mutant lamin A that causes Emery-Dreifuss muscular dystrophy inhibits in vitro differentiation of C2C12 myoblasts.

Molecular and cellular biology - 1 Feb 2004

Favreau Catherine, Higuet Dominique, Courvalin Jean-Claude, Buendia Brigitte

Abstract excerpt

Autosomal dominantly inherited missense mutations in lamins A and C cause several tissue-specific diseases, including Emery-Dreifuss muscular dystrophy (EDMD) and Dunnigan-type familial partial lipodystrophy (FPLD). Here we analyze myoblast-to-myotube differentiation in C2C12 clones overexpressin...

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Identifiers

PMID: 14749366
DOI: 10.1128/MCB.24.4.1481-1492.2004
PMCID: PMC344177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14749366-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Expression of a mutant lamin A that causes Emery-Dreifuss muscular dystrophy inhibits in vitro differentiation of C2C12 myoblasts.PMID 14749366Read ↗

Differentiation of C2C12 myoblasts expressing lamin A mutated at a site responsible for Emery-Dreifuss muscular dystrophy is improved by inhibition of the MEK-ERK pathway and stimulation of the PI3-kinase pathway.Semantic proximity Read ↗

Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy.Semantic proximity Read ↗

Remodelling of the nuclear lamina and nucleoskeleton is required for skeletal muscle differentiation in vitro.Semantic proximity Read ↗

Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery-Dreifuss muscular dystrophy.Semantic proximity Read ↗

Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation.Semantic proximity Read ↗

Role of Cdkn2a in the Emery-Dreifuss Muscular Dystrophy Cardiac Phenotype.Semantic proximity Read ↗

LMNA Mutations G232E and R482L Cause Dysregulation of Skeletal Muscle Differentiation, Bioenergetics, and Metabolic Gene Expression Profile.Semantic proximity Read ↗

The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin.Semantic proximity Read ↗

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Lamins A and C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy.Semantic proximity Read ↗

Failure of lamin A/C to functionally assemble in R482L mutated familial partial lipodystrophy fibroblasts: altered intermolecular interaction with emerin and implications for gene transcription.Semantic proximity Read ↗

Consequences of Lmna Exon 4 Mutations in Myoblast FunctionSemantic proximity Read ↗

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