Article

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

2018-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the human LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A and C, cause autosomal dominant Emery-Dreifuss muscular dystrophy, congenital muscular dystrophy, limb-girdle muscular dystrophy, and other diseases collectively known as laminopathies. The molecular mechanisms responsible for these diseases remain incompletely understood, but the muscle-specific defects...

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Literature Corpus work: 9b5751f1-e52e-5629-a64f-b3414c9d8fc8
DOI: 10.1101/364778

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