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Article

The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.

Channels (Austin, Tex.) - 1 Jan 2000

Fallen Katherine, Banerjee Sreedatta, Sheehan Jonathan, Addison Daniel, Lewis L Michelle, Meiler Jens, Denton Jerod S

Abstract excerpt

The renal inward rectifying potassium channel Kir1.1 plays key roles in regulating electrolyte homeostasis and blood pressure. Loss-of-function mutations in the channel cause a life-threatening salt and water balance disorder in infants called antenatal Bartter syndrome (ABS). Of more than 30 ABS mutations identified, approximately half are located in the intracellular domain of the channel. The mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19221509
DOI: 10.4161/chan.3.1.7817
PMCID: PMC7968143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.PMID 19221509Read ↗

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Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning.Semantic proximity Read ↗

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Identification of Rare Variants Causing Early-Onset Bartter Syndrome: a Clinical, Genetic, and Biophysical StudySemantic proximity Read ↗

Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel.Semantic proximity Read ↗

pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.Semantic proximity Read ↗

KirBac1.1: it's an inward rectifying potassium channel.Semantic proximity Read ↗

Genome mining yields new disease-associated ROMK variants with distinct defectsSemantic proximity Read ↗

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