Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis C virus-related resistance mechanisms to interferon alpha-based antiviral therapy.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Feb 2005

Hofmann Wolf Peter, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

Only 50-60% of the patients chronically infected with the hepatitis C virus (HCV) achieve a sustained virologic response to the current standard antiviral therapy consisting of pegylated interferon alpha in combination with ribavirin. The definite reasons for virologic response or non-response to interferon alpha-based therapy are unknown. Besides host and treatment efficacy factors, it is presumable that HCV is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Therapy, Combination

Share to Hepacivirus

Share to Interferon-alpha

Share to Ribavirin

Share to Viral Envelope Proteins

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 15653410
DOI: 10.1016/j.jcv.2004.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis C virus-related resistance mechanisms to interferon alpha-based antiviral therapy.PMID 15653410Read ↗

Understanding the molecular mechanism(s) of hepatitis C virus (HCV) induced interferon resistance.Semantic proximity Read ↗

Hepatitis C virus, the E2 envelope protein, and alpha-interferon resistance.Semantic proximity Read ↗

Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response.Semantic proximity Read ↗

Hepatitis C virus and interferon resistance.Semantic proximity Read ↗

The molecular basis for responsiveness to anti-viral therapy in hepatitis C.Semantic proximity Read ↗

Genetic diversity of the hepatitis C virus: Impact and issues in the antiviral therapySemantic proximity Read ↗

Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection.Semantic proximity Read ↗

Mutations within protein kinase R-binding domain of NS5A protein of hepatitis C virus (HCV) and specificity of HCV antibodies in pretreatment sera of HCV-chronically infected patients and their effect on the result of treatment.Semantic proximity Read ↗

Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy.Semantic proximity Read ↗

Mutations in the NS5A and E2‐PePHD region of hepatitis C virus type 1b and correlation with the response to combination therapy with interferon and ribavirinSemantic proximity Read ↗

Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.Semantic proximity Read ↗

Mutations in the E2 and NS5A regions in patients infected with hepatitis C virus genotype 1a and their correlation with response to treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.