Article
Mutations within protein kinase R-binding domain of NS5A protein of hepatitis C virus (HCV) and specificity of HCV antibodies in pretreatment sera of HCV-chronically infected patients and their effect on the result of treatment.
Japanese journal of infectious diseases - 1 Apr 2006
Kmieciak Dariusz, Kruszyna Łukasz, Migdalski Paweł, Łaciński Mariusz, Juszczyk Jacek, Trzeciak Wiesław H
Abstract excerpt
We analyzed protein kinase R (PKR)-binding domain sequences of hepatitis C virus (HCV) NS5A protein and the profile of HCV-specific antibodies from pretreatment sera of HCV-chronically infected patients. Results were compared with clinical data to verify their influence on the course and result of therapy. Of 9 patients enrolled in a 12-month treatment with pegylated interferon alpha (PEG-IFN-alpha) plus...
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