Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response.

Hepatology (Baltimore, Md.) - 1 Jun 2000

Sarrazin C, Kornetzky I, Rüster B, Lee J H, Kronenberger B, Bruch K, Roth W K, Zeuzem S

Abstract excerpt

Defined regions of hepatitis C virus (HCV) envelope 2 (E2), PePHD, and nonstructural 5A (NS5A) protein (PKR-binding domain) have been shown to interact with interferon alfa (IFN-alpha)-inducible double-stranded RNA-activated protein kinase (PKR) in vitro, suggesting a possible mechanism of HCV to evade antiviral effects of IFN-alpha. The clinical correlation between amino acid mutations within the E2 PePHD or the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C

Share to Interferon-alpha

Share to Molecular Conformation

Share to Ribavirin

Share to Viral Envelope Proteins

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 10827164
DOI: 10.1053/jhep.2000.7987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response.PMID 10827164Read ↗

Mutations in the E2-PePHD and NS5A region of hepatitis C virus type 1 and the dynamics of hepatitis C viremia decline during interferon alfa treatment.Semantic proximity Read ↗

Mutations within the hepatitis C virus genotype 1b E2-PePHD domain do not correlate with treatment outcome.Semantic proximity Read ↗

Mutations in E2-PePHD, NS5A-PKRBD, NS5A-ISDR, and NS5A-V3 of hepatitis C virus genotype 1 and their relationships to pegylated interferon-ribavirin treatment responses.Semantic proximity Read ↗

Quasispecies heterogeneity of the carboxy-terminal part of the E2 gene including the PePHD and sensitivity of hepatitis C virus 1b isolates to antiviral therapy.Semantic proximity Read ↗

Mutations in the E2 and NS5A regions in patients infected with hepatitis C virus genotype 1a and their correlation with response to treatment.Semantic proximity Read ↗

Mutations in the NS5A and E2‐PePHD region of hepatitis C virus type 1b and correlation with the response to combination therapy with interferon and ribavirinSemantic proximity Read ↗

Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon.Semantic proximity Read ↗

Mutations in two PKR-binding domains in chronic hepatitis C of genotype 3a and correlation with viral loads and interferon responsiveness.Semantic proximity Read ↗

Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response.Semantic proximity Read ↗

Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection.Semantic proximity Read ↗

Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy.Semantic proximity Read ↗

Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.