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Article

Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation.

Mechanisms of development - 1 Feb 2005

Molotkova Natalia, Molotkov Andrei, Sirbu I Ovidiu, Duester Gregg

Abstract excerpt

Studies in amphibian embryos have suggested that retinoic acid (RA) may function as a signal that stimulates posterior differentiation of the nervous system as postulated by the activation-transformation model for anteroposterior patterning of the nervous system. We have tested this hypothesis in retinaldehyde dehydrogenase-2 (Raldh2) null mutant mice lacking RA synthesis in the somitic mesoderm. Raldh2(-/-)...

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Identifiers

PMID: 15652703
DOI: 10.1016/j.mod.2004.10.008
PMCID: PMC2826194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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