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Article

Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2005

Molotkov Andrei, Molotkova Natalia, Duester Gregg

Abstract excerpt

Studies on nonmammalian vertebrate embryos have indicated that retinoic acid (RA) is required for pancreas development. We have analyzed mouse embryos carrying a null mutation of the gene encoding retinaldehyde dehydrogenase 2 (Raldh2), which controls RA synthesis. Raldh2-/- embryos specifically lack expression of Pdx1 (a homeobox gene required for pancreas development) and Prox1 in dorsal endodermal but not...

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PMID: 15739227
DOI: 10.1002/dvdy.20256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development.PMID 15739227Read ↗

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