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Article

Effects of cyclic nucleotides on the function of prestin.

The Journal of physiology - 1 Mar 2005

Deák Levente, Zheng Jing, Orem Alex, Du Guo-Guang, Aguiñaga Salvador, Matsuda Keiji, Dallos Peter

Abstract excerpt

Outer hair cells (OHCs) in the mammalian organ of Corti display electromotility, which is thought to provide the local active mechanical amplification of the cochlear response. Prestin is the key molecule responsible for OHC electromotility. Several compounds, including cGMP, have been shown to influence OHC electromotility. There are two potential cAMP/cGMP-dependent protein kinase phosphorylation sites on...

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Identifiers

PMID: 15649974
DOI: 10.1113/jphysiol.2004.078857
PMCID: PMC1665600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effects of cyclic nucleotides on the function of prestin.PMID 15649974Read ↗

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A new mutation in the human pres gene and its effect on prestin function.Semantic proximity Read ↗

Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.Semantic proximity Read ↗

N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Interaction of prestin (SLC26A5) with monovalent intracellular anions.Semantic proximity Read ↗

The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits.Semantic proximity Read ↗

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplificationSemantic proximity Read ↗

Current carried by the Slc26 family member prestin does not flow through the transporter pathway.Semantic proximity Read ↗

Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifierSemantic proximity Read ↗

Normal hearing sensitivity at low-to-middle frequencies with 34% prestin-charge density.Semantic proximity Read ↗

Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin.Semantic proximity Read ↗

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