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Article

A new mutation in the human pres gene and its effect on prestin function.

International journal of molecular medicine - 1 Oct 2007

Toth Timea, Deak Levente, Fazakas Ferenc, Zheng Jing, Muszbek Laszlo, Sziklai Istvan

Abstract excerpt

The electromotility of cochlear outer hair cells (OHCs) is a major factor in cochlear amplification that enhances the sensitivity of hearing in humans. Prestin is associated with presumed conformational changes in an integral membrane protein. Prestin knockout (-/-) mice display loss of OHC elect...

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Source

Identifiers

PMID: 17786286

Genes

GJB2
GJB6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17786286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new mutation in the human pres gene and its effect on prestin function.PMID 17786286Read ↗

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplificationSemantic proximity Read ↗

The R130S mutation significantly affects the function of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Effects of cyclic nucleotides on the function of prestin.Semantic proximity Read ↗

Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin.Semantic proximity Read ↗

The V499G/Y501H mutation impairs fast motor kinetics of prestin and has significance for defining functional independence of individual prestin subunits.Semantic proximity Read ↗

The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing loss.Semantic proximity Read ↗

The C-terminus of prestin influences nonlinear capacitance and plasma membrane targeting.Semantic proximity Read ↗

Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier.Semantic proximity Read ↗

The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing lossSemantic proximity Read ↗

N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein.Semantic proximity Read ↗

Normal hearing sensitivity at low-to-middle frequencies with 34% prestin-charge density.Semantic proximity Read ↗

Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifierSemantic proximity Read ↗

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