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Article

STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy.

International journal of molecular medicine - 1 Feb 2005

Yukawa Kazunori, Kishino Masanori, Goda Mikako, Liang Xiang-Ming, Kimura Akihiko, Tanaka Tetsuji, Bai Tao, Owada-Makabe Kyoko, Tsubota Yuji, Ueyama Takashi, Ichinose Masakazu, Maeda Masanobu, Takeda Kiyoshi, Akira Shizuo

Abstract excerpt

To elucidate the contribution of signal transducer and activator of transcription (STAT) 6 to the pathophysiology of chronic renal injury, STAT6-/- mice were subjected to unilateral ureteral ligation together with wild-type control mice. STAT6-/- kidneys had more apoptotic cells and a greater influx of F4/80-positive cells than wild-type kidneys following ureteral obstruction. There was a much larger alpha-smooth...

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Source

Identifiers

PMID: 15647835

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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