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Article

Role of TRPC6 in kidney damage after acute ischemic kidney injury.

Scientific reports - 22 Feb 2022

Zheng Zhihuang, Tsvetkov Dmitry, Bartolomaeus Theda Ulrike Patricia, Erdogan Cem, Krügel Ute, Schleifenbaum Johanna, Schaefer Michael, Nürnberg Bernd, Chai Xiaoning, Ludwig Friedrich-Alexander, N'diaye Gabriele, Köhler May-Britt, Wu Kaiyin, Gollasch Maik, Markó Lajos

Abstract excerpt

Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca2+ and other monovalent cations into cells, is widely expressed in the kidney. TRPC6 gene variations have been linked to chronic kidney disease but its role in acute kidney injury (AKI) is unknown. Here we aimed to investigate the putative role of TRPC6 channels in AKI. We used Trpc6-/-...

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Identifiers

PMID: 35194063
DOI: 10.1038/s41598-022-06703-9
PMCID: PMC8864023

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