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Article

Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.

Kidney international - 1 Apr 2017

Wu Yueh-Lin, Xie Jian, An Sung-Wan, Oliver Noelynn, Barrezueta Nestor X, Lin Mei-Hsiang, Birnbaumer Lutz, Huang Chou-Long

Abstract excerpt

Fibrosis is an exaggerated form of tissue repair that occurs with serious damage or repetitive injury and ultimately leads to organ failure due to the excessive scarring. Increased calcium ion entry through the TRPC6 channel has been associated with the pathogenesis of heart and glomerular diseases, but its role in renal interstitial fibrosis is unknown. We studied this by deletion of Trpc6 in mice and found it...

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Source

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Identifiers

PMID: 27979597
DOI: 10.1016/j.kint.2016.09.039
PMCID: PMC5357448

Genes

TRPC6
TRPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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