Article
STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Feb 2018
Yokota Tsubasa, Omachi Kohei, Suico Mary Ann, Kamura Misato, Kojima Haruka, Fukuda Ryosuke, Motomura Keishi, Teramoto Keisuke, Kaseda Shota, Kuwazuru Jun, Takeo Toru, Nakagata Naomi, Shuto Tsuyoshi, Kai Hirofumi
Abstract excerpt
Background: Alport syndrome (AS) is a hereditary, progressive nephritis caused by mutation of type IV collagen. Previous studies have shown that activation of signal transducer and activator of transcription 3 (STAT3) exacerbates other renal diseases, but whether STAT3 activation exacerbates AS pathology is still unknown. Here we aim to investigate the involvement of STAT3 in the progression of AS. Method:...
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