Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased bone formation in mice lacking apolipoprotein E.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2005

Schilling Arndt F, Schinke Thorsten, Münch Christian, Gebauer Matthias, Niemeier Andreas, Priemel Matthias, Streichert Thomas, Rueger Johannes M, Amling Michael

Abstract excerpt

UNLABELLED: ApoE is a plasma protein that plays a major role in lipoprotein metabolism. Here we describe that ApoE expression is strongly induced on mineralization of primary osteoblast cultures. ApoE-deficient mice display an increased bone formation rate compared with wildtype controls, thereby showing that ApoE has a physiologic function in bone remodeling. INTRODUCTION: Apolipoprotein E (ApoE) is a protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Resorption

Share to Durapatite

Share to Lipoproteins

Share to Osteoblasts

Share to Osteocalcin

Share to Radioimmunoassay

Source

Identifiers

PMID: 15647822
DOI: 10.1359/JBMR.041101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased bone formation in mice lacking apolipoprotein E.PMID 15647822Read ↗

The role of apolipoprotein E in bone metabolism.Semantic proximity Read ↗

Atorvastatin Promotes Bone Formation in Aged apoE–/– Mice through the Sirt1–Runx2 AxisSemantic proximity Read ↗

Alzheimer’s disease risk factor APOE4 exerts dimorphic effects on female boneSemantic proximity Read ↗

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone HomeostasisSemantic proximity Read ↗

Apolipoprotein E and the Apolipoprotein E-Deficient MouseSemantic proximity Read ↗

Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice.Semantic proximity Read ↗

Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice.Semantic proximity Read ↗

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein ESemantic proximity Read ↗

Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification.Semantic proximity Read ↗

Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.Semantic proximity Read ↗

Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner.Semantic proximity Read ↗

Increased bone formation in osteocalcin-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.