Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms.

Critical care medicine - 1 Jan 2005

Watanabe Eizo, Hirasawa Hiroyuki, Oda Shigeto, Matsuda Kenichi, Hatano Masahiko, Tokuhisa Takeshi

Abstract excerpt

OBJECTIVE: To determine the allelic frequencies of interleukin (IL)-6-, IL-1-, and tumor necrosis factor-alpha (TNF)-related gene polymorphisms in critically ill patients with extremely high IL-6 blood level and to examine the genetic effects on their clinical courses. DESIGN: Population-based association study. SETTING: A general intensive care unit in a university teaching hospital. PATIENTS: A total of 150...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Critical Illness
Share to Hospital Mortality

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1

Share to Interleukin 1 Receptor Antagonist Protein

Share to Multiple Organ Failure

Share to Outcome Assessment, Health Care

Share to Sialoglycoproteins

Share to Systemic Inflammatory Response Syndrome

Source

Identifiers

PMID: 15644653
DOI: 10.1097/01.ccm.0000150025.79100.7d

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms.PMID 15644653Read ↗

Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications.Semantic proximity Read ↗

Tumour necrosis factor-α plus interleukin-10 low producer phenotype predicts acute kidney injury and death in intensive care unit patients.Semantic proximity Read ↗

Interleukin-6: it’s role in the organism, genetic polymorphism and significance in certain diseases (literature review)Semantic proximity Read ↗

Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.Semantic proximity Read ↗

Association between inflammatory genetic polymorphism and acute lung injury after cardiac surgery with cardiopulmonary bypass.Semantic proximity Read ↗

Association between Interleukin-6 Promoter Polymorphism (-174 G/C), Serum Interleukin-6 Levels and Mortality in Severe Septic Patients.Semantic proximity Read ↗

Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients'.Semantic proximity Read ↗

Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients.Semantic proximity Read ↗

Association of TNF-α-308 (G >A) (rs1800629) Gene Polymorphism with Adverse Outcomes of Sepsis in Critically Ill Patients.Semantic proximity Read ↗

The association of interleukin 6 haplotype clades with mortality in critically ill adults.Semantic proximity Read ↗

The interleukin-6 (IL6)-174 G/C promoter genotype is associated with the presence of septic shock and the ex vivo secretion of IL6.Semantic proximity Read ↗

Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.