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Article

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

The Journal of biological chemistry - 1 Apr 2005

Niimura Manabu, Isoo Noriko, Takasugi Nobumasa, Tsuruoka Makiko, Ui-Tei Kumiko, Saigo Kaoru, Morohashi Yuichi, Tomita Taisuke, Iwatsubo Takeshi

Abstract excerpt

Gamma-secretase cleaves type I transmembrane proteins, including beta-amyloid precursor protein and Notch, and requires the formation of a protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2 for its activity. Aph-1 is implicated in the stabilization of this complex, although its precise mechanistic role remains unknown. Substitution of the first glycine within the transmembrane GXXXG motif of...

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PMID: 15644323
DOI: 10.1074/jbc.M409829200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.PMID 15644323Read ↗

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.Semantic proximity Read ↗

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Semantic proximity Read ↗

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.Semantic proximity Read ↗

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.Semantic proximity Read ↗

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.Semantic proximity Read ↗

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic DevelopmentSemantic proximity Read ↗

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.Semantic proximity Read ↗

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities.Semantic proximity Read ↗

Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.Semantic proximity Read ↗

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.Semantic proximity Read ↗

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathologySemantic proximity Read ↗

Intramembrane proteolysis by gamma-secretase.Semantic proximity Read ↗

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