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Article

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.

The Journal of cell biology - 26 May 2003

Hu Yue, Fortini Mark E

Abstract excerpt

The gamma-secretase complex is required for intramembrane cleavage of several integral membrane proteins, including the Notch receptor, where it generates an active signaling fragment. Four putative gamma-secretase components have been identified-presenilin (Psn), nicastrin (Nct), Aph-1, and Pen-2. Here, we use a stepwise coexpression approach to investigate the role of each new component in gamma-secretase...

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Identifiers

PMID: 12771124
DOI: 10.1083/jcb.200304014
PMCID: PMC2199374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.PMID 12771124Read ↗

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Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Semantic proximity Read ↗

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