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Article

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.

Journal of molecular neuroscience : MN - 1 Jan 2006

Araki Wataru, Saito Shinya, Takahashi-Sasaki Noriko, Shiraishi Hirohisa, Komano Hiroto, Murayama Kiyoko S

Abstract excerpt

APH-1 is one of the four essential components of presenilin (PS)-gamma-secretase complexes. There are three major isoforms of APH-1 in humans: APH-1aS, APH-1aL, and APH-1b. To gain insight into the functional role of APH-1 in gamma-secretase complexes, we analyzed the relationship between the three APH-1 forms and characterized APH-1 mutants with a disrupted transmembrane GxxxG motif. We found that overexpression...

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PMID: 16757808
DOI: 10.1385/JMN:29:1:35

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.PMID 16757808Read ↗

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