Article
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Developmental cell - 1 Jul 2002
Francis Ross, McGrath Garth, Zhang Jianhuan, Ruddy David A, Sym Mary, Apfeld Javier, Nicoll Monique, Maxwell Mark, Hai Bing, Ellis Michael C, Parks Annette L, Xu Wei, Li Jinhe, Gurney Mark, Myers Richard L, Himes Carol S, Hiebsch Ronald, Ruble Cara, Nye Jeffrey S, Curtis Daniel
Abstract excerpt
Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins. A C. elegans genetic screen revealed two genes, aph-1 and pen-2, encoding multipass transmembrane proteins, that interact strongly with sel-12/presenilin and aph-2/nicastrin. Human aph-1 and pen-2 partially rescue the C. elegans mutant phenotypes, demonstrating conserved...
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