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Article

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Goutte Caroline, Tsunozaki Makoto, Hale Valerie A, Priess James R

Abstract excerpt

Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates. Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gene as a new component of the Notch pathway in...

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Identifiers

PMID: 11792846
DOI: 10.1073/pnas.022523499
PMCID: PMC117381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.PMID 11792846Read ↗

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