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Article

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

The Journal of biological chemistry - 3 Sept 2004

Edbauer Dieter, Kaether Christoph, Steiner Harald, Haass Christian

Abstract excerpt

gamma-Secretase is an intramembrane-cleaving aspartyl protease complex that mediates the final cleavage of beta-amyloid precursor protein to liberate the neurotoxic amyloid-beta peptide implicated in Alzheimer's disease. The four proteins presenilin (PS), nicastrin (NCT), APH-1, and PEN-2 are suf...

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Identifiers

PMID: 15210705
DOI: 10.1074/jbc.M406228200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15210705-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.PMID 15210705Read ↗

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.Semantic proximity Read ↗

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.Semantic proximity Read ↗

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.Semantic proximity Read ↗

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.Semantic proximity Read ↗

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.Semantic proximity Read ↗

Specific Mutations in Aph1 Cause γ-Secretase Activation.Semantic proximity Read ↗

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Semantic proximity Read ↗

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Semantic proximity Read ↗

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.Semantic proximity Read ↗

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.Semantic proximity Read ↗

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic DevelopmentSemantic proximity Read ↗

Intramembrane proteolysis by gamma-secretase.Semantic proximity Read ↗

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