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Article

Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.

The Journal of biological chemistry - 30 Jan 2004

Fortna Ryan R, Crystal Adam S, Morais Vanessa A, Pijak Donald S, Lee Virginia M-Y, Doms Robert W

Abstract excerpt

APH-1, presenilin, nicastrin, and Pen-2 are proteins with varying membrane topologies that compose the gamma-secretase complex, which is responsible for the intramembrane proteolysis of several substrates including the amyloid precursor protein. APH-1 is known to be necessary for gamma-secretase activity, but its precise function in the complex is not fully understood, and its membrane topology has not been...

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PMID: 14593096
DOI: 10.1074/jbc.M310505200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.PMID 14593096Read ↗

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