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Article

Force transmission, compliance, and viscoelasticity are altered in the alpha7-integrin-null mouse diaphragm.

American journal of physiology. Cell physiology - 1 Feb 2005

Lopez M A, Mayer U, Hwang W, Taylor T, Hashmi M A, Jannapureddy S R, Boriek Aladin M

Abstract excerpt

Alpha7beta1 integrin is a transmembrane structural and receptor protein of skeletal muscles, and the absence of alpha7-integrin causes muscular dystrophy. We hypothesized that the absence of alpha7-integrin alters compliance and viscoelasticity and disrupts the mechanical coupling between passive transverse and axial contractile elements in the diaphragm. In vivo the diaphragm is loaded with pressure, and...

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Identifiers

PMID: 15643051
DOI: 10.1152/ajpcell.00362.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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