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Article

Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture

8 Nov 2004

Abstract excerpt

BACKGROUND: Stromal fibroblasts associated with in situ and invasive breast carcinoma differ phenotypically from fibroblasts associated with normal breast epithelium, and these alterations in carcinoma-associated fibroblasts (CAF) may promote breast carcinogenesis and cancer progression. A better understanding of the changes that occur in fibroblasts during carcinogenesis and their influence on epithelial cell...

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PMID: 15642169
DOI: 10.1186/bcr949

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