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Article

Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.

Cancer letters - 28 Dec 2012

Lühr Inke, Friedl Andreas, Overath Thorsten, Tholey Andreas, Kunze Thomas, Hilpert Felix, Sebens Susanne, Arnold Norbert, Rösel Frank, Oberg Hans-Heinrich, Maass Nicolai, Mundhenke Christoph, Jonat Walter, Bauer Maret

Abstract excerpt

Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of...

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Identifiers

PMID: 22776560
DOI: 10.1016/j.canlet.2012.06.014
PMCID: PMC3708601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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