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Article

Cancer risk and the ATM gene: a continuing debate.

Journal of the National Cancer Institute - 17 May 2000

Khanna K K

Abstract excerpt

Deficiencies in the ability of cells to sense and repair damage in individuals with rare genetic instability syndromes increase the risk of developing cancer. Ataxia-telangiectasia (A-T), such a condition, is associated with a high incidence of leukemia and lymphoma that develop in childhood. Although A-T is an autosomal recessive disorder, some penetrance appears in individuals with one mutated ATM gene (A-T...

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Identifiers

PMID: 10814674
DOI: 10.1093/jnci/92.10.795

Genes

ATM

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Cancer risk and the ATM gene: a continuing debate.PMID 10814674Read ↗

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