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Article

ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer

5 Sept 2017

Abstract excerpt

Abstract Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility, and ATM somatic mutations have been identified in resected human pancreatic tumors. Here we investigated how Atm contributes to pancreatic cancer by deleting this gene in a murine model of the disease expressing oncogenic Kras (Kras G12D ). We show...

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PMID: 28894253
DOI: 10.1038/s41598-017-11661-8

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