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Article

The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes.

Journal of cell science - 1 Oct 1998

Logarinho E, Sunkel C E

Abstract excerpt

The MPM2 antibody is a valuable tool for studying the regulation of mitotic events since it specifically recognises a subset of mitosis-specific phosphoproteins. Some MPM2 epitopes have been shown to be phosphorylated by p34(cdc2). However, recent results suggest that the newly emerging family of polo-like kinases (Plks) may also act as MPM2 kinases. In this study, we present evidence suggesting that the...

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PMID: 9730982
DOI: 10.1242/jcs.111.19.2897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes.PMID 9730982Read ↗

Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles.Semantic proximity Read ↗

polo encodes a protein kinase homolog required for mitosis in Drosophila.Semantic proximity Read ↗

Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster.Semantic proximity Read ↗

Mutations in mákos, a Drosophila gene encoding the Cdc27 subunit of the anaphase promoting complex, enhance centrosomal defects in polo and are suppressed by mutations in twins/aar, which encodes a regulatory subunit of PP2A.Semantic proximity Read ↗

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts.Semantic proximity Read ↗

Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.Semantic proximity Read ↗

Association of polo-like kinase with α-, β- and γ-tubulins in a stable complexSemantic proximity Read ↗

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.Semantic proximity Read ↗

Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe.Semantic proximity Read ↗

Metaphase arrest with centromere separation in polo mutants of Drosophila.Semantic proximity Read ↗

Polo-like kinase-activating kinasesSemantic proximity Read ↗

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.Semantic proximity Read ↗

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