Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional gene discovery using hybrid ribozyme libraries.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004

Kato Yoshio, Tsunemi Masaru, Miyagishi Makoto, Kawasaki Hiroaki, Taira Kazunari

Abstract excerpt

Hybrid ribozymes that couple the cleavage activity of hammerhead ribozymes with the unwinding activity of RNA helicases are powerful tools in the study of cell genetics and pharmaceutical drug development. They are useful for targeting a specific gene as well as screening functional genes to show phenotypic alterations. By randomizing the binding arms within the ribozymes, we can create a library of ribozymes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Primers
Share to Gene Library
Share to Indicators and Reagents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Plasmids

Share to Protein Multimerization

Share to Restriction Mapping

Share to RNA, Catalytic

Source

Identifiers

PMID: 15017054
DOI: 10.1385/1-59259-746-7:245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional gene discovery using hybrid ribozyme libraries.PMID 15017054Read ↗

Hammerhead ribozyme-based target discovery.Semantic proximity Read ↗

Chemistry-based RNA technologies: demonstration of usefulness of libraries of ribozymes and short hairpin RNAs (shRNAs).Semantic proximity Read ↗

Functional gene-discovery systems based on libraries of hammerhead and hairpin ribozymes and short hairpin RNAs.Semantic proximity Read ↗

Synthetic Hammerhead Ribozymes as Therapeutic Tools to Control Disease GenesSemantic proximity Read ↗

Ribozymes as therapeutic tools for genetic disease.Semantic proximity Read ↗

Ribozyme gene therapy: applications for molecular medicine.Semantic proximity Read ↗

A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries.Semantic proximity Read ↗

Direct selection for ribozyme cleavage activity in cells.Semantic proximity Read ↗

Optimization of molecular tools for high-throughput genetic screeningSemantic proximity Read ↗

Elucidating Evolutionary Mechanisms and Variants of the Hammerhead Ribozyme Using In Vitro Selection.Semantic proximity Read ↗

High-Throughput Analysis and Engineering of Ribozymes and Deoxyribozymes by Sequencing.Semantic proximity Read ↗

Use of ribozymes to inhibit gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.