Article
A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism.
Lipids - 1 Aug 2004
Valachovic Martin, Wilcox Lisa I, Sturley Stephen L, Bard Martin
Abstract excerpt
A mutation in an otherwise nonessential ERG2 gene is synthetically lethal when combined with mutations in two transcription factors encoded by the UPC2 and ECM22 genes. Employing UV mutagenesis, we isolated a suppressor of the triple mutant erg2delta upc2delta ecm22delta. The morpholine-resistant phenotype of the suppressor was used to identify the suppressor as a mutation in the ELO3 gene. In an expression study...
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