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Article

Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans.

Lipids - 1 Nov 1993

Bard M, Lees N D, Turi T, Craft D, Cofrin L, Barbuch R, Koegel C, Loper J C

Abstract excerpt

The identification of the precise structural features of yeast sterol molecules required for the essential "sparking" function has been a controversial area of research. Recent cloning and gene disruption studies in Saccharomyces cerevisiae have shown that C-24 methylation (ERG6), C-5 desaturation (ERG3) and delta 8-delta 7 isomerization (ERG2) are not required, while C-14 demethylation (ERG11) and C-14 reduction...

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Source

Identifiers

PMID: 8277826
DOI: 10.1007/BF02537115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans.PMID 8277826Read ↗

Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.Semantic proximity Read ↗

A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.Semantic proximity Read ↗

Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.Semantic proximity Read ↗

Aerobic isolation of an ERG24 null mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site.Semantic proximity Read ↗

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.Semantic proximity Read ↗

Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.Semantic proximity Read ↗

The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway.Semantic proximity Read ↗

A specific structural requirement for ergosterol in long-chain fatty acid synthesis mutants important for maintaining raft domains in yeast.Semantic proximity Read ↗

Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.Semantic proximity Read ↗

Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Transcriptional regulation by ergosterol in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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