Article
In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity.
Biochimica et biophysica acta - 4 Jul 2003
Mo C, Milla P, Athenstaedt K, Ott R, Balliano G, Daum G, Bard M
Abstract excerpt
In Saccharomyces cerevisiae, the 3-keto reductase (Erg27p) encoded by ERG27 gene is one of the key enzymes involved in the C-4 demethylation of the sterol intermediate, 4,4-dimethylzymosterol. The oxidosqualene cyclase (Erg7p) encoded by the ERG7 gene converts oxidosqualene to lanosterol, the first cyclic component of sterol biosynthesis. In a previous study, we found that erg27 strains grown on cholesterol- or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.