Article
Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Feb 2005
Håkansson Anna, Westberg Lars, Nilsson Staffan, Buervenich Silvia, Carmine Andrea, Holmberg Björn, Sydow Olof, Olson Lars, Johnels Bo, Eriksson Elias, Nissbrandt Hans
Abstract excerpt
The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association...
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