Article
Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology.
PloS one - 1 Jan 2012
Domart Marie-Charlotte, Hobday Tina M C, Peddie Christopher J, Chung Gary H C, Wang Alan, Yeh Karen, Jethwa Nirmal, Zhang Qifeng, Wakelam Michael J O, Woscholski Rudiger, Byrne Richard D, Collinson Lucy M, Poccia Dominic L, Larijani Banafshé
Abstract excerpt
The functions and morphology of cellular membranes are intimately related and depend not only on their protein content but also on the repertoire of lipids that comprise them. In the absence of in vivo data on lipid asymmetry in endomembranes, it has been argued that motors, scaffolding proteins or integral membrane proteins rather than non-lamellar bilayer lipids such as diacylglycerol (DAG), are responsible for...
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