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Article

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice.

Development (Cambridge, England) - 1 Aug 2014

Tilak Anup, Nelsen Sylvia M, Kim Hyung-Seok, Donley Nathan, McKnite Autumn, Lee Hyunjung, Christian Jan L

Abstract excerpt

ProBMP4 is generated as a latent precursor that is sequentially cleaved at two sites within the prodomain to generate an active ligand. An initial cleavage occurs adjacent to the ligand domain, which generates a non-covalently associated prodomain/ligand complex that is subsequently dissociated by cleavage at an upstream site. An outstanding question is whether the two sites need to be cleaved sequentially and in...

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Identifiers

PMID: 24993941
DOI: 10.1242/dev.110130
PMCID: PMC4197676

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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