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Article

Site-specific cleavage of BMP4 by furin, PC6, and PC7.

The Journal of biological chemistry - 2 Oct 2009

Nelsen Sylvia M, Christian Jan L

Abstract excerpt

Bone morphogenetic proteins (BMPs) require proteolytic activation by members of the proprotein convertase (PC) family. Pro-BMP4 is initially cleaved at a site adjacent to the mature ligand domain (S1) and then at an upstream site (S2) within the prodomain. Cleavage at the S2 site, which appears to occur in a tissue-specific fashion, regulates the activity and signaling range of mature BMP4. To test the hypothesis...

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Source

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Identifiers

PMID: 19651771
DOI: 10.1074/jbc.M109.028506
PMCID: PMC2785643

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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