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Article

Mouse Models of Human Proprotein Convertase Insufficiency

31 Dec 2020

Abstract excerpt

The kexin-like proprotein convertases perform the initial proteolytic cleavages that ultimately generate a variety of different mature peptide and proteins, ranging from brain neuropeptides to endocrine peptide hormones, to structural proteins, among others. In this review, we present a general introduction to proprotein convertase structure and biochemistry, followed by a comprehensive discussion of each member...

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PMID: 33382413
DOI: 10.1210/endrev/bnaa033

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