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Article

Factor H binds to washed human platelets.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2005

Vaziri-Sani F, Hellwage J, Zipfel P F, Sjöholm A G, Iancu R, Karpman D

Abstract excerpt

BACKGROUND: Factor H regulates the alternative pathway of complement. The protein has three heparin-binding sites, is synthesized primarily in the liver and copurifies from platelets with thrombospondin-1. Factor H mutations at the C-terminus are associated with atypical hemolytic uremic syndrome, a condition in which platelets are consumed. Objectives The aim of this study was to investigate if factor H...

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Source

Identifiers

PMID: 15634279
DOI: 10.1111/j.1538-7836.2004.01010.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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