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Article

Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation.

Blood - 1 Jun 2008

Ståhl Anne-lie, Vaziri-Sani Fariba, Heinen Stefan, Kristoffersson Ann-Charlotte, Gydell Karl-Henrik, Raafat Reem, Gutierrez Alberto, Beringer Ortraud, Zipfel Peter F, Karpman Diana

Abstract excerpt

Atypical hemolytic uremic syndrome (aHUS) may be associated with mutations in the C-terminal of factor H (FH). FH binds to platelets via the C-terminal as previously shown using a construct consisting of short consensus repeats (SCRs) 15 to 20. A total of 4 FH mutations, in SCR15 (C870R) and SCR20 (V1168E, E1198K, and E1198Stop) in patients with aHUS, were studied regarding their ability to allow complement...

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Identifiers

PMID: 18268093
DOI: 10.1182/blood-2007-08-106153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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