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Article

Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome.

Blood - 1 Sept 2007

Józsi Mihály, Strobel Stefanie, Dahse Hans-Martin, Liu Wei-shih, Hoyer Peter F, Oppermann Martin, Skerka Christine, Zipfel Peter F

Abstract excerpt

The atypical form of the kidney disease hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. In addition to mutations in complement regulators, factor H (FH)-specific autoantibodies have been reported for aHUS patients. The aim of the present study was to understand the role of these autoantibodies in aHUS. First, the binding sites of FH autoantibodies from 5 unrelated aHUS...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17495132
DOI: 10.1182/blood-2007-02-071472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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