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Article

Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Nov 2014

Choi Min Sik, Nakamura Tomohiro, Cho Seung-Je, Han Xuemei, Holland Emily A, Qu Jing, Petsko Gregory A, Yates John R, Liddington Robert C, Lipton Stuart A

Abstract excerpt

Emerging evidence suggests that oxidative/nitrosative stress, as occurs during aging, contributes to the pathogenesis of Parkinson's disease (PD). In contrast, detoxification of reactive oxygen species and reactive nitrogen species can protect neurons. DJ-1 has been identified as one of several recessively inherited genes whose mutation can cause familial PD, and inactivation of DJ-1 renders neurons more...

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Identifiers

PMID: 25378175
DOI: 10.1523/JNEUROSCI.4751-13.2014
PMCID: PMC4220036

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.PMID 25378175Read ↗

Neurodegeneration: Impact of S-nitrosylated Parkin, DJ-1 and PINK1 on the pathogenesis of Parkinson's disease.Semantic proximity Read ↗

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondriaSemantic proximity Read ↗

Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.Semantic proximity Read ↗

DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative StressSemantic proximity Read ↗

Aberrant Protein S-Nitrosylation Mimics the Effect of Rare Genetic Mutations in Neurodegenerative Diseases.Semantic proximity Read ↗

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.Semantic proximity Read ↗

A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunctionSemantic proximity Read ↗

DJ-1 has a role in antioxidative stress to prevent cell death.Semantic proximity Read ↗

Modulation of signaling pathways by DJ-1: An updated overviewSemantic proximity Read ↗

Mutational analysis of DJ-1 in <i>Drosophila</i> implicates functional inactivation by oxidative damage and agingSemantic proximity Read ↗

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damageSemantic proximity Read ↗

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.Semantic proximity Read ↗

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