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Article

Nanocrystal-based bioelectronic coding of single nucleotide polymorphisms.

Journal of the American Chemical Society - 12 Jan 2005

Liu Guodong, Lee Thomas M H, Wang Joseph

Abstract excerpt

A bioelectronic method for coding unknown single nucleotide polymorphisms (SNPs) based on the use of different encoding nanocrystals is described. Four such nanocrystals, ZnS, CdS, PbS, and CuS, linked to the adenosine, cytidine, guanosine and thymidine mononucleotides, respectively, are sequentially introduced to the DNA hybrid-coated magnetic-bead solution. Each mutation captures via base pairing different...

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PMID: 15631437
DOI: 10.1021/ja043780a

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