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Room-temperature single-nucleotide polymorphism and multiallele DNA detection using fluorescent nanocrystals and microarrays.

Analytical chemistry - 15 Sept 2003

Gerion Daniele, Chen Fanqing, Kannan Balaji, Fu Aihua, Parak Wolfgang J, Chen David J, Majumdar Arunava, Alivisatos A Paul

Abstract excerpt

We report two cDNA microarray-based applications of DNA-nanocrystal conjugates, single-nucleotide polymorphism (SNP) and multiallele detections, using a commercial scanner and two sets of nanocrystals with orthogonal emissions. We focus on SNP mutation detection in the human p53 tumor suppressor gene, which has been found to be mutated in more than 50% of the known human cancers. DNA-nanocrystal conjugates are...

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PMID: 14674452
DOI: 10.1021/ac034482j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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