Article

Treatment of anti-myeloperoxidase glomerulonephritis using recombinant deoxyribonuclease I is enhanced by adeno-associated virus gene therapy

2024-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Extracellular DNA (ecDNA) released from injured and dying cells powerfully induces injurious inflammation. In this study we define the role of ecDNA in systemic vasculitis affecting the kidney, using human kidney biopsies and murine models of myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA GN). Twice daily administration of intravenous DNase I (ivDNas...

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Literature Corpus work: bde90f76-fc45-5b1d-b8a5-2798aed6acf4
DOI: 10.1101/2024.09.09.612148

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